The Predominant Th1 Cytokine Profile in Maternal Plasma of Preeclamptic Women Is Not Reflected in the Choriodecidual and Fetal Compartments
- 1 July 2005
- journal article
- Published by Springer Science and Business Media LLC in Journal of the Society for Gynecologic Investigation
- Vol. 12 (5), 335-342
- https://doi.org/10.1016/j.jsgi.2005.02.005
Abstract
Objective: Human pregnancy disorders such as preeclampsia are thought to involve variations in cytokine levels. It has been proposed that, in preeclamptic women, a balance favoring the Th1-type over the Th2-type cytokine profile determines local or systemic immunologic responses to pregnancy and that this may cause defective placental implantation and placental ischemia, which activate systemic endothelial cells. The purpose of this study was to determine whether cytokine expression differs in the maternal, choriodecidual, and fetal compartments, and between women with or without preeclampsia.Keywords
This publication has 37 references indexed in Scilit:
- Linear '2–0–1' lymphocyte development: hypotheses on cellular bases for immunityTrends in Immunology, 2003
- Activated Umbilical Cord Blood Cells from Pre-term and Term Neonates Express CD69 and Synthesize IL-2 but Are Unable to Produce IFN-γPublished by Elsevier BV ,2003
- The Expressions of Intracellular Cytokines in the Lymphocytes of Preeclamptic PatientsAmerican Journal of Reproductive Immunology, 2002
- Absence of enhanced systemic inflammatory response at 18 weeks of gestation in women with subsequent pre‐eclampsiaBJOG: An International Journal of Obstetrics and Gynaecology, 2002
- Transforming growth factor β 1 levels in platelet depleted plasma in African women with pre-eclampsiaJournal of Obstetrics and Gynaecology, 2002
- Flow Cytometric Measurement of Intracellular Th1 and Th2 Cytokine Production by Human Villous and Extravillous CytotrophoblastPlacenta, 2001
- Role of hormone-controlled Th1- and Th2-type cytokines in successful pregnancyJournal of Neuroimmunology, 2000
- Spontaneous and Induced Release of Prostaglandins, Interleukin (IL)‐1β, IL‐6, and Tumor Necrosis Factor‐α by Placental Tissue from Normal and Preeclamptic PregnanciesAmerican Journal of Reproductive Immunology, 1999
- Trophoblast Deportation in Human Pregnancy—its Relevance for Pre-eclampsiaPlacenta, 1999
- Immunolocalization of tumour necrosis factor-α (TNF-α) in the placental bed of normotensive and hypertensive human pregnanciesPlacenta, 1998