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Synthesis of Pyrrolopyrimidines and Thienopyrimidines
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Synthesis of Pyrrolopyrimidines and Thienopyrimidines
Synthesis of Pyrrolopyrimidines and Thienopyrimidines
HO
Haruo Ogura
Haruo Ogura
MS
Masakazu Sakaguchi
Masakazu Sakaguchi
KT
Kazuyoshi Takeda
Kazuyoshi Takeda
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1 January 1972
journal article
Published by
Pharmaceutical Society of Japan
in
CHEMICAL & PHARMACEUTICAL BULLETIN
Vol. 20
(2)
,
404-408
https://doi.org/10.1248/cpb.20.404
Abstract
7-Substituted 1, 3-dimethyl-7
H
-2, 4, 6-(5
H
, 6
H
) pyrrolo [2, 3-d] pyrimidinetriones (IIIa, b, c) were prepared from 6-amino-1, 3-dimethyluracil (I) and ethyl α-bromoacetate. Reactionof I and α-bromo-ketones afforded 6, 7-disubstituted 1, 3-dimethyl-7
H
-2, 4-pyrrolo-[2, 3-d] pyrimidinediones (IV, V, VI). On the other hand, reaction of 6-mercapto-1, 3-dimethyluracil (VIII) and cc-bromocarbonyl compound afforded thieno [2, 3-d] pyrimidines (X, XI).
Keywords
SUBSTITUTED
IIIA
DIMETHYL
PYRROLOPYRIMIDINES
THIENOPYRIMIDINES
BROMOCARBONYL
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Cited by 10 articles