Why Doesn't Imatinib Cure Chronic Myeloid Leukemia?
- 1 February 2010
- journal article
- review article
- Published by Oxford University Press (OUP) in The Oncologist
- Vol. 15 (2), 182-186
- https://doi.org/10.1634/theoncologist.2009-0297
Abstract
Imatinib mesylate has transformed the treatment for chronic myeloid leukemia (CML). The vast majority of patients obtain hematologic remission, with a low probability of progression of disease. Yet imatinib rarely cures CML, and current recommendations dictate lifelong treatment with imatinib. In this review we analyze the biology behind the failure of imatinib to fully eradicate CML. We review evidence that indicates that the leukemic stem cell for CML is inherently resistant to imatinib, and that imatinib treatment itself may enhance this resistance.Keywords
This publication has 40 references indexed in Scilit:
- A progenitor cell origin of myeloid malignanciesProceedings of the National Academy of Sciences of the United States of America, 2009
- Proteasome Inhibition Causes Regression of Leukemia and Abrogates BCR-ABL–Induced Evasion of Apoptosis in Part through Regulation of Forkhead Tumor SuppressorsCancer Research, 2009
- Persistence of Leukemia-Initiating Cells in a Conditional Knockin Model of an Imatinib-Responsive Myeloproliferative DisorderCancer Cell, 2009
- Synergy between Proteasome Inhibitors and Imatinib Mesylate in Chronic Myeloid LeukemiaPLOS ONE, 2009
- Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression dataBlood, 2008
- PML targeting eradicates quiescent leukaemia-initiating cellsNature, 2008
- Loss of β-Catenin Impairs the Renewal of Normal and CML Stem Cells In VivoCancer Cell, 2007
- Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylateBlood, 2006
- Dynamics of chronic myeloid leukaemiaNature, 2005
- Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid LeukemiaNew England Journal of Medicine, 2003