Efficient Pd-Catalyzed Amination of Heteroaryl Halides
- 10 August 2005
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (18), 3965-3968
- https://doi.org/10.1021/ol0514754
Abstract
The Pd-catalyzed amination of a variety of heteroaryl halides has been accomplished by utilizing bulky electron-rich biaryl phosphine ligands. In particular, we report the first couplings of amines with chloro- and bromoindoles bearing a free NH, as well as the first Pd-catalyzed aminations of a 5-halopyrimidine. [reaction: see text]Keywords
This publication has 7 references indexed in Scilit:
- Understanding the Coupling of Heteroaromatic Substrates: Synthesis, Structures, and Reductive Eliminations of Heteroarylpalladium Amido ComplexesOrganometallics, 2003
- Scope and Mechanism of Palladium-Catalyzed Amination of Five-Membered Heterocyclic HalidesThe Journal of Organic Chemistry, 2003
- Mild and Efficient Copper-Catalyzed Amination of Aryl Bromides with Primary AlkylaminesOrganic Letters, 2003
- Synthesis of Secondary and Tertiary Aminothiophenes via Palladium-Catalyzed AminationThe Journal of Organic Chemistry, 2001
- Palladium catalysed amination of electron deficient halothiophenesTetrahedron Letters, 2000
- Rational Development of Practical Catalysts for Aromatic Carbon−Nitrogen Bond FormationAccounts of Chemical Research, 1998
- A Simple Catalytic Method for the Conversion of Aryl Bromides to ArylaminesAngewandte Chemie-International Edition, 1995