Aberrant Methylation of Preproenkephalin and p16 Genes in Pancreatic Intraepithelial Neoplasia and Pancreatic Ductal Adenocarcinoma

Publisher Website
Google Scholar
Abstract
Intraductal lesions are commonly found in the pancreatic ducts adjacent to invasive ductal adenocarcinoma, and have been regarded as precursor lesions of pancreatic ductal adenocarcinoma.1 x 1 Kozuka, S, Sassa, R, Taki, T, Masamoto, K, Nagasawa, S, Saga, S, Hasegawa, K, and Takeuchi, M. Relation of pancreatic duct hyperplasia to carcinoma. Cancer. 1979; 43: 1418–1428 Crossref | PubMed | Scopus (281) | Google Scholar See all References , 2 x 2 Hruban, RH, Adsay, NV, Albores-Saavedra, J, Compton, C, Garrett, ES, Goodman, SN, Kern, SE, Klimstra, DS, Klöppel, G, Longnecker, DS, Lüttges, J, and Offerhaus, GJ. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol. 2001; 25: 579–586 Crossref | PubMed | Scopus (813) | Google Scholar See all References , 3 x 3 Klöppel, G, Hruban, RH, Longnecker, DS, Adler, G, Kern, SE, and Partanen, TJ. Ductal adenocarcinoma of the pancreas. in: SR Hamilton, LA Aaltonen (Eds.) Pathology and Genetics, Tumors of the Digestive System, World Health Organization Classification of Tumors. IARCP Press, Lyon; 2000: 221–230 Google Scholar See all References Recently, pancreatic ductal lesions, previously described as hyperplasias or dysplasias, have been reclassified into four groups of pancreatic intraepithelial neoplasias (PanINs): PanIN-1A, -1B, -2, and -3.2 x 2 Hruban, RH, Adsay, NV, Albores-Saavedra, J, Compton, C, Garrett, ES, Goodman, SN, Kern, SE, Klimstra, DS, Klöppel, G, Longnecker, DS, Lüttges, J, and Offerhaus, GJ. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol. 2001; 25: 579–586 Crossref | PubMed | Scopus (813) | Google Scholar See all References , 3 x 3 Klöppel, G, Hruban, RH, Longnecker, DS, Adler, G, Kern, SE, and Partanen, TJ. Ductal adenocarcinoma of the pancreas. in: SR Hamilton, LA Aaltonen (Eds.) Pathology and Genetics, Tumors of the Digestive System, World Health Organization Classification of Tumors. IARCP Press, Lyon; 2000: 221–230 Google Scholar See all References Molecular analysis of PanIN lesions could help refine the PanIN classification and provide insights into molecular events important to the pathogenesis of early pancreatic ductal adenocarcinoma.