An Enzymatic Mechanism for the Antithrombotic and Antihemostatic Actions of Aspirin
- 25 January 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 183 (4122), 325-327
- https://doi.org/10.1126/science.183.4122.325
Abstract
Aspirin-type drugs may inhibit irreversible clumping of human blood platelets by blocking the enzymatic conversion of arachidonic acid to a hitherto undiscovered factor, labile aggregation-stimulating substance, which triggers aggregation and to prostaglandin E2, which sensitizes the platelets to its aggregatory effects.Keywords
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