A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets
Open Access
- 11 September 2014
- journal article
- Published by American Society of Hematology in Blood
- Vol. 124 (11), 1808-1815
- https://doi.org/10.1182/blood-2014-01-550335
Abstract
Key Points: Thrombus formation and contraction alters local molecular transport, which regulates agonist distribution and platelet activation. Semaphorin 4D contact-dependent signaling increases platelet activation, but does not affect platelet packing or agonist transport.Keywords
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