The Effects on Aqueous Dynamics of PhXA41, a New Prostaglandin F2α Analogue, After Topical Application in Normal and Ocular Hypertensive Human Eyes
- 1 October 1993
- journal article
- clinical trial
- Published by American Medical Association (AMA) in American Journal of Ophthalmology
- Vol. 111 (10), 1351-1358
- https://doi.org/10.1001/archopht.1993.01090100059027
Abstract
Objective: To study the effects of a topically applied prostaglandin F2α analogue, PhXA41 (Latanoprost; 13,14-dihydro-17-phenyl-18,19,20-trinor-prostaglandin F2α-isopropyl ester), on aqueous dynamics in the human eye. Design: A randomized, double-masked study was carried out on 20 normal and 20 ocular hypertensive humans. One eye of each subject was treated with 0.006% PhXA41, while the contralateral eye received placebo twice daily for 5 days. Main Outcome: Compared with placebo, PhXA41 reduced intraocular pressure in both groups by approximately 20%. Results: Tonographic facility of outflow was increased 24% in the normal group and 30% in the ocular hypertensive group; no changes were observed in the rates of aqueous humor flow in either group. The changes in tonographic facility were insufficient to fully explain the ocular hypotensive effect of the drug, suggesting that PhXA41 enhances outflow via the uveoscleral pathway. The suitability of fluorophotometry as a measure of flow was confirmed by three methods of comparing blood-aqueous barrier permeability: polarization of cameral fluorescence, intensity of backscattered light from the anterior chamber (flare), and cameral fluorescence after oral administration of fluorescein sodium. All of these measured parameters were normal, suggesting that this compound has no clinically significant effects on the blood-aqueous barrier or on the accuracy of fluorophotometry. PhXA41 was well tolerated in both groups. Only four of 40 subjects reported a transient foreign-body sensation, and only one of 40 subjects was observed to have greater than moderate conjunctival hyperemia. Most subjects had no symptoms and no measurable hyperemia. Conclusions: These results suggest that PhXA41 is a potentially useful ocular hypotensive agent that enhances the egress of aqueous humor via both major outflow pathways. The relative lack of ocular side effects in this study further suggests that this agent has promise for the treatment of chronic glaucoma.Keywords
This publication has 10 references indexed in Scilit:
- Phenyl substituted prostaglandin analogs for glaucoma treatmentDrugs of the Future, 1992
- Effects of prostaglandin D2 and its analogue, BW245C, on intraocular pressure in humansAlbrecht von Graefes Archiv für Ophthalmologie, 1991
- Additivity of Prostaglandin F2α-1-Isopropyl Ester to Timolol in Glaucoma PatientsOphthalmology, 1991
- The Effect of Adding Prostaglandin F2α-Isopropylester to Timolol in Patients With Open Angle GlaucomaAmerican Journal of Ophthalmology, 1990
- Prostaglandin F2α increases uveoscleral outflow in the cynomolgus monkeyExperimental Eye Research, 1989
- Increased uveoscleral outflow as a possible mechanism of ocular hypotension caused by prostaglandin F2α-1-isopropylester in the cynomolgus monkeyExperimental Eye Research, 1989
- Prostaglandin F2α-1-Isopropylester Lowers Intraocular Pressure Without Decreasing Aqueous Humor FlowAmerican Journal of Ophthalmology, 1988
- Topical Prostaglandin E2 Effects on Normal Human Intraocular PressureJournal of Ocular Pharmacology and Therapeutics, 1988
- Fluorescence polarization measurement of binding of fluorescein to albuminExperimental Eye Research, 1982
- New methods of measuring the rate of aqueous flow in man with fluoresceinExperimental Eye Research, 1966