Inhibitory Activity of Cinnamon Bark Species and their Combination Effect with Acarbose against Intestinal α-glucosidase and Pancreatic α-amylase
- 3 May 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Plant Foods for Human Nutrition
- Vol. 66 (2), 143-148
- https://doi.org/10.1007/s11130-011-0226-4
Abstract
Inhibition of α-glucosidase and pancreatic α-amylase is one of the therapeutic approaches for delaying carbohydrate digestion, resulting in reduced postprandial glucose. The aim of this study was to evaluate the phytochemical analysis and the inhibitory effect of various cinnamon bark species against intestinal α-glucosidase and pancreatic α-amylase. The results showed that the content of total phenolic, flavonoid, and condensed tannin ranged from 0.17 to 0.21 g gallic acid equivalent/g extract, from 48.85 to 65.52 mg quercetin equivalent/g extract, and from 0.12 to 0.15 g catechin equivalent/g extract, respectively. The HPLC fingerprints of each cinnamon species were established. Among cinnamon species, Thai cinnamon extract was the most potent inhibitor against the intestinal maltase with the IC50 values of 0.58 ± 0.01 mg/ml. The findings also showed that Ceylon cinnamon was the most effective intestinal sucrase and pancreatic α-amylase inhibitor with the IC50 values of 0.42 ± 0.02 and 1.23 ± 0.02 mg/ml, respectively. In addition, cinnamon extracts produced additive inhibition against intestinal α-glucosidase and pancreatic α-amylase when combined with acarbose. These results suggest that cinnamon bark extracts may be potentially useful for the control of postprandial glucose in diabetic patients through inhibition of intestinal α-glucosidase and pancreatic α-amylase.Keywords
This publication has 29 references indexed in Scilit:
- Inhibitory Activities of Cyanidin and Its Glycosides and Synergistic Effect with Acarbose against Intestinal α-Glucosidase and Pancreatic α-AmylaseInternational Journal of Molecular Sciences, 2010
- Glycated haemoglobin and blood pressure‐lowering effect of cinnamon in multi‐ethnic Type 2 diabetic patients in the UK: a randomized, placebo‐controlled, double‐blind clinical trialDiabetic Medicine, 2010
- Metabolic Effects of Fructose and the Worldwide Increase in ObesityPhysiological Reviews, 2010
- Plasma Glucose Concentration and Prediction of Future Risk of Type 2 DiabetesDiabetes Care, 2009
- A series of cinnamic acid derivatives and their inhibitory activity on intestinal α-glucosidaseJournal of Enzyme Inhibition and Medicinal Chemistry, 2009
- Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated ReceptorsPPAR Research, 2008
- Antioxidative Effects of Polyphenols in Leaves ofHouttuynia cordataon Protein Fragmentation by Copper–Hydrogen PeroxideIn VitroJournal of Medicinal Food, 2005
- Antidiabetic effect ofCinnamomum cassia andCinnamomum zeylanicum In vivo andIn vitroPhytotherapy Research, 2005
- Effect of heat treatments on alpha-amylase inhibitor activity in sorghum (Sorghum bicolour L.)Plant Foods for Human Nutrition, 1993
- Therapeutic Potentials of Acarbose as First-Line Drug in NIDDM Insufficiently Treated With Diet AloneDiabetes Care, 1991