Antiviral activity of a derivative of the photosensitive compound Hypericin
- 1 September 1996
- journal article
- Published by Elsevier BV in Phytomedicine
- Vol. 3 (2), 185-190
- https://doi.org/10.1016/s0944-7113(96)80034-1
Abstract
Eight synthetic compounds related to the photosensitive antiviral quinonic plant compound hypericin were screened for light-mediated antiviral activity. The compound 2,5,9,12-tetra(carboxyethylthiomethyl) hypericin was found to have activity against membrane-enveloped Sindbis virus and murine cytomegalovirus but not against the non-enveloped poliovirus. The activity of this compound was investigated in more detail. The mechanism of action appeared to be of the photosensitive singlet oxygen type and the activity could be reduced by the presence of a singlet oxygen quencher molecule. The membrane proteins of Sindbis virus were found not to be altered by treatment with this compound or hypericin, although the derivative did affect the electrophoretic mobility of the capsid protein.Keywords
This publication has 21 references indexed in Scilit:
- Chemiluminescent activation of the antiviral activity of hypericin: a molecular flashlight.Proceedings of the National Academy of Sciences of the United States of America, 1994
- Photodynamic Inactivation of Radiation Leukemia Virus Produced from Hypericin-Treated CellsVirology, 1993
- The importance of light in the anti-HIV effect of hypericinAntiviral Research, 1993
- Inactivation of the Human Immunodeficiency Virus by Hypericin: Evidence for Photochemical Alterations of p24 and a Block in UncoatingAIDS Research and Human Retroviruses, 1992
- Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirusAntiviral Research, 1992
- In vitro virucidal activity of selected anthraquinones and anthraquinone derivativesAntiviral Research, 1991
- PHOTOSENSITIZATION IS REQUIRED FOR INACTIVATION OF EQUINE INFECTIOUS ANEMIA VIRUS BY HYPERICINPhotochemistry and Photobiology, 1991
- HYPERICIN AND ITS PHOTODYNAMIC ACTIONPhotochemistry and Photobiology, 1986
- HypericismPublished by Springer Science and Business Media LLC ,1980
- Membrane biogenesis. In vitro cleavage, core glycosylation, and integration into microsomal membranes of sindbis virus glycoproteins.The Journal of cell biology, 1979