Early Neutrophilia Is Associated With Volume of Ischemic Tissue in Acute Stroke
- 1 February 2008
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 39 (2), 355-360
- https://doi.org/10.1161/strokeaha.107.490128
Abstract
Background and Purpose— Few data exist on the relationship between differential subpopulations of peripheral leukocytes and early cerebral infarct size in ischemic stroke. Using diffusion-weighted MR imaging (DWI), we assessed the relationship of early total and differential peripheral leukocyte counts and volume of ischemic tissue in acute stroke. Methods— All included patents had laboratory investigations and neuroimaging collected within 24 hours of stroke onset. Total peripheral leukocyte counts and differential counts were analyzed individually and by quartiles. DWI lesions were outlined using a semiautomated threshold technique. The relationship between leukocyte quartiles and DWI infarct volumes was examined using multivariate quartile regression. Results— 173 patients met study inclusion criteria. Median age was 73 years. Total leukocyte counts and DWI volumes showed a strong correlation (Spearman rho=0.371, P P for trend P =0.004). After multivariate analysis, larger DWI volume remained strongly associated with higher total leukocyte and neutrophil counts (both probability values P =0.4971). Compared with the lowest quartiles, DWI volumes were 8.7 mL and 12.9 mL larger in the highest quartiles of leukocyte and neutrophil counts, respectively. Conclusions— Higher peripheral leukocyte and neutrophil counts, but not lymphocyte counts, are associated with larger infarct volumes in acute ischemic stroke. Attenuating neutrophilic response early after ischemic stroke may be a viable therapeutic strategy and warrants further study.Keywords
This publication has 30 references indexed in Scilit:
- The inflammatory response in strokeJournal of Neuroimmunology, 2006
- Statin Use is Independently Associated with Smaller Infarct Volume in Nonlacunar MCA Territory StrokeJournal of Neuroimaging, 2006
- Inflammation and AtherosclerosisStroke, 2006
- Inflammation, Atherosclerosis, and StrokeThe Neurologist, 2006
- C-Reactive Protein and White Blood Cell Count Increases in the First 24 Hours after Acute StrokeCerebrovascular Diseases, 2004
- Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN)Stroke, 2003
- Beyond MismatchStroke, 2003
- Quantile RegressionJournal of Economic Perspectives, 2001
- Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.Stroke, 1993
- Peripheral white blood cell count in cerebral ischemic infarctionActa Neurologica Scandinavica, 1985