Discordant placental echogenicity: a novel sign of impaired placental perfusion in twin-twin transfusion syndrome?
Open Access
- 11 December 2009
- journal article
- case report
- Published by Taylor & Francis Ltd in The Journal of Maternal-Fetal & Neonatal Medicine
- Vol. 23 (1), 103-106
- https://doi.org/10.3109/14767050903005873
Abstract
Twin-twin transfusion syndrome (TTTS) is present in approximately 5–15% of monochorionic-diamniotic twin pregnancies. A chronic blood flow imbalance through placental vascular anastomoses from the donor to the recipient twin is considered the pathophysiologic mechanism responsible for the development of TTTS. Discordant echogenicity between the donor and recipient placenta has been proposed in a previous case report as an additional sonographic sign of TTTS. Here, we present a case of TTTS with discordant placental echogenicity characterized by a hyperechoic and thicker placental side in the donor twin associated with reduced vascular Doppler signals, histologic lesions suggestive of ischemic changes, and overexpression of anti-angiogenic factors.Keywords
This publication has 6 references indexed in Scilit:
- Twin-to-twin transfusion syndrome: an antiangiogenic state?American Journal of Obstetrics and Gynecology, 2008
- Placental diagnostic criteria and clinical correlation – a workshop reportPlacenta, 2005
- Expression of vascular endothelial growth factor, placental growth factor, and their receptors Flt-1 and KDR in human placenta under pathologic conditionsHuman Pathology, 2002
- Staging of Twin-Twin Transfusion SyndromeJournal of Perinatology, 1999
- Stuck twin syndrome without signs of twin‐to‐twin transfusionUltrasound in Obstetrics & Gynecology, 1998
- Severe twin-to-twin transfusion syndrome: a new sonographic feature of the placentaUltrasound in Obstetrics & Gynecology, 1997