IL‐3 and Peripheral blood stem cell harvesting
- 1 January 1993
- journal article
- review article
- Published by Oxford University Press (OUP) in The International Journal of Cell Cloning
- Vol. 11 (3), 173-181
- https://doi.org/10.1002/stem.5530110303
Abstract
Transplantation of blood‐derived stem cells is increasingly performed because when used alone or when combined with autologous bone marrow grafting, it can demonstrably shorten myelosuppression following multi‐agent chemotherapy. Hematopoieric growth factors can mobilize peripheral blood stem cells from the bone marrow to therapeutically intervene in accelerating hematologic recovery. Interleukin 3 (IL‐3), whose hematopoietic activities were first described some ten years ago, is one of several candidate growth factors that may prove useful in enhancing this mobilization in order to obtain adequate yields of circulating stem cells for transplantation. IL‐3 used in conjunction with synergistically acting cytokines such as granulocyte‐macrophage colony stimulating factor (GM‐CSF) or granulocyte CSF (G‐CSF) have already yielded interesting results, while new factors like stem cell factor are in the process of clinical evaluations and appear promising. However, further issues remain to be clarified to confirm the general applicability of cytokine‐augmented peripheral blood stem cells in improving on‐schedule delivery of high‐dose myelosuppressive chemotherapy in patients with malignancies.Keywords
This publication has 40 references indexed in Scilit:
- The capacity of peripheral blood stem cells mobilised with chemotherapy plus G-CSF to repopulate irradiated marrow stroma in vitro is similar to that of bone marrowEuropean Journal Of Cancer, 1992
- Mobilization of circulating hemopoietic progenitor cells by rhIL-3 and rhGM-CSF in primatesThe International Journal of Cell Cloning, 1992
- The engraftment capacity of peripheral blood progenitor cells (PBPC) mobilised with chemotherapy ± G-CSFThe International Journal of Cell Cloning, 1992
- The use of rhIL-3 for mobilization of peripheral blood The International Journal of Cell Cloning in previously treated patients with lymphoid malignanciesThe International Journal of Cell Cloning, 1992
- Recombinant human stem cell factor stimulates increased numbers of peripheral blood and marrow CFU-GM, BFU-E, CFU-MIX, HPP-CFC and CD34 + cells in baboonsThe International Journal of Cell Cloning, 1992
- Peripheral blood expansion of early progenitor cells after high-dose cyclophosphamide and rhGM-CSFEuropean Journal of Cancer and Clinical Oncology, 1991
- Large-scale collection of circulating haematopoietic progenitors in cancer patients treated with high-dose cyclophosphamide and recombinant human GM-CSFEuropean Journal of Cancer and Clinical Oncology, 1990
- The recovery of circulating progenitor cells after chemotherapy in AML and ALL and its relation to the rate of bone marrow regeneration after aplasiaBritish Journal of Haematology, 1989
- Effect of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Chemotherapy-Induced MyelosuppressionNew England Journal of Medicine, 1988
- PERIPHERAL BLOOD STEM CELL AUTOGRAFTING: A NEW THERAPEUTIC OPTION FOR AML?British Journal of Haematology, 1987