Muscle development, regeneration and laminopathies: how lamins or lamina-associated proteins can contribute to muscle development, regeneration and disease
Open Access
- 10 November 2012
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Life Sciences
- Vol. 70 (15), 2713-2741
- https://doi.org/10.1007/s00018-012-1190-3
Abstract
The aim of this review article is to evaluate the current knowledge on associations between muscle formation and regeneration and components of the nuclear lamina. Lamins and their partners have become particularly intriguing objects of scientific interest since it has been observed that mutations in genes coding for these proteins lead to a wide range of diseases called laminopathies. For over the last 10 years, various laboratories worldwide have tried to explain the pathogenesis of these rare disorders. Analyses of the distinct aspects of laminopathies resulted in formulation of different hypotheses regarding the mechanisms of the development of these diseases. In the light of recent discoveries, A-type lamins—the main building blocks of the nuclear lamina—together with other key elements, such as emerin, LAP2α and nesprins, seem to be of great importance in the modulation of various signaling pathways responsible for cellular differentiation and proliferation.Keywords
This publication has 263 references indexed in Scilit:
- Defects in Glycosylation Impair Satellite Stem Cell Function and Niche Composition in the Muscles of the Dystrophic Large myd MouseThe International Journal of Cell Cloning, 2012
- Mapping of lamin A- and progerin-interacting genome regionsChromosoma, 2012
- Exome Sequencing and Functional Analysis Identifies BANF1 Mutation as the Cause of a Hereditary Progeroid SyndromeAmerican Journal of Human Genetics, 2011
- Assessment of the Myogenic Stem Cell Compartment Following Transplantation of Pax3/Pax7-Induced Embryonic Stem Cell-Derived ProgenitorsThe International Journal of Cell Cloning, 2011
- Embryonic and adult isoforms of XLAP2 form microdomains associated with chromatin and the nuclear envelopeCell and tissue research, 2011
- Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA geneBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2010
- Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle developmentDevelopmental Dynamics, 2010
- Deconstructing Stem Cell Tumorigenicity: A Roadmap to Safe Regenerative MedicineThe International Journal of Cell Cloning, 2009
- Reduced expression of A-type lamins and emerin activates extracellular signal-regulated kinase in cultured cellsBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009
- Asymmetric Self-Renewal and Commitment of Satellite Stem Cells in MuscleCell, 2007