Reactions Following Completion of 1 and 2 Year Multidrug Therapy (MDT)
- 1 September 2010
- journal article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 83 (3), 637-644
- https://doi.org/10.4269/ajtmh.2010.09-0586
Abstract
We evaluated the incidence, severity, and duration of reactional states in 139 multibacillary (MB) leprosy patients in the first 2 years after the completion of the 1 year regimen of multidrug therapy (MDT) currently recommended by the World Health Organization (WHO) and compared those findings with 295 MB leprosy patients treated with the same regimen previously recommended for 2 years. During the first year after the completion of 1 year MDT, patients experienced 1 or more reactional states 27% of the time, the vast majority being lepra type 1 reactions (reversal reactions, RR), whereas patients who received 2 year MDT experienced a reactional state during that time period only 8% of the time (P < 0.001). Furthermore, during the first year after the completion of therapy, and during the first 2 years, both the number of reactional states and reversal reactions were significantly (P < or = 0.004) more frequent, severe, of longer duration, and more commonly associated with neuritis.This publication has 28 references indexed in Scilit:
- The Relapse Rate in MB Leprosy Patients Treated with 2-Years of WHO-MDT is Not Low1Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2004
- High levels of inflammatory cytokines are associated with poor clinical response to steroid treatment and recurrent episodes of type 1 reactions in leprosyClinical and Experimental Immunology, 2002
- Immunohistochemical Analysis of Cellular Infiltrate and Gamma Interferon, Interleukin-12, and Inducible Nitric Oxide Synthase Expression in Leprosy Type 1 (Reversal) Reactions before and during Prednisolone TreatmentInfection and Immunity, 2001
- THE MANAGEMENT OF ERYTHEMA NODOSUM LEPROSUM: CURRENT AND FUTURE OPTIONSLeprosy Review, 1996
- Tumour necrosis factor-alpha (TNF-α) synthesis is associated with the skin and peripheral nerve pathology of leprosy reversal reactionsClinical and Experimental Immunology, 1995
- Type 1 reaction, neuritis and disability in leprosy. What is the current epideiniological situation?Leprosy Review, 1994
- Field evaluation of WHO-MDT of fixed duration, at ALERT, Ethiopia: the AMFES project-II. Reaction and neuritis during and after MDT in PB and MB leprosy patientsLeprosy Review, 1994
- Reactions in Leprosy: an Epidemiological Study of 3 86 Patients in West NepalLeprosy Review, 1994
- Analysis of naturally occurring delayed-type hypersensitivity reactions in leprosy by in situ hybridization.The Journal of Experimental Medicine, 1989
- ERYTHEMA NODOSUM LEPROSUM: A CLINICAL MANIFESTATION OF THE ARTHUS PHENOMENONThe Lancet, 1969