Peritonitis induces the synthesis of 1α,25‐dihydroxyvitamin D3 in macrophages from CAPD patients
- 17 August 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 220 (2), 307-310
- https://doi.org/10.1016/0014-5793(87)80836-0
Abstract
Metabolism of 25-[3H]hydroxyvitamin D3 was studied in peritoneal macrophages from renal failure patients on continuous ambulatory peritoneal dialysis (CAPD). Cells from 5 out of 8 patients with a history of peritonitis produced significant amounts of a metabolite chromatographically identical to 1α,25(OH)2D3; but none was produced by cells from non-infected patients. The evidence strongly suggests that peritoneal macrophages stimulated by infection can metabolise 25OHD3 to the active vitamin D3 metabolite, 1α,25(OH)2D3, when maintained in short-term primary cultureKeywords
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