Control of Cisplatin-Induced Emesis With Intravenous Ondansetron Plus Intravenous Dexamethasone
- 1 June 2000
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in American Journal of Clinical Oncology
- Vol. 23 (3), 253-257
- https://doi.org/10.1097/00000421-200006000-00009
Abstract
Two hundred seventy-five patients were enrolled in one of two arms in a crossover fashion. Arm A: three 8-mg doses of ondansetron intravenous (IV) were given at 4-hour intervals plus dexamethasone 20 mg IV from the start of chemotherapy followed by dexamethasone 5 mg IV every 12 hours. Arm B: as in arm A but with three 8-mg doses of ondansetron IV were given at 24-hour intervals substituted for ondansetron IV given at 4-hour intervals. There were 237 patients in arm A and 223 patients in arm B. Complete protection from acute and delayed vomiting/nausea obtained in arm A was 94.5%/90.3% and 71.3%/57.8%, respectively; protection obtained in arm B was 92.7%/91.0% and 71.7%/60.5%, respectively. No differences were observed in control of acute emesis after the addition of dexamethasone to ondansetron, given as either a triple 8-mg dose at 4-hour intervals or a single 8-mg dose. The triple dose of ondansetron given at 24-hour intervals was also not more effective than ondansetron given at 4-hour intervals in preventing delayed emesis when dexamethasone was added. However, the former improved control of delayed nausea on day 2. Adverse events tended to be minor, with constipation and hiccup the most common.Keywords
This publication has 15 references indexed in Scilit:
- Ondansetron versus metoclopramide, both combined with dexamethasone, in the prevention of cisplatin-induced delayed emesis. The Italian Group for Antiemetic Research.Journal of Clinical Oncology, 1997
- The Severity and Pattern of Emesis following Different Cytotoxic AgentsOncology, 1996
- Cisplatin and Emesis: Aspects of Treatment and a New Trial for Delayed Emesis Using Oral Dexamethasone plus Ondansetron Beginning at 16 Hours after CisplatinOncology, 1996
- Optimal Control of Acute Cisplatin-lnduced EmesisOncology, 1996
- Management of Cisplatin-lnduced Delayed EmesisOncology, 1996
- Cisplatin-induced delayed emesis: Pattern and prognostic factors during three subsequent cyclesAnnals of Oncology, 1994
- Comparison of the anti-emetic efficacy of different doses of ondansetron, given as either a continuous infusion or a single intravenous dose, in acute cisplatin-induced emesis. A multicentre, double-blind, randomised, parallel group studyBritish Journal of Cancer, 1992
- Does dexamethasone enhance control of acute cisplatin induced emesis by ondansetron?BMJ, 1991
- Comparison of ondansetron and ondansetron plus dexamethasone as antiemetic prophylaxis during cisplatin-containing chemotherapyThe Lancet, 1991
- Prevention of cisplatin-induced emesis: a double-blind multicenter randomized crossover study comparing ondansetron and ondansetron plus dexamethasone.Journal of Clinical Oncology, 1991