Adolescents with acute lymphoblastic leukaemia: Emerging from the shadow of paediatric and adult treatment protocols
- 8 February 2006
- journal article
- review article
- Published by Wiley in Pediatric Blood & Cancer
- Vol. 47 (6), 748-756
- https://doi.org/10.1002/pbc.20776
Abstract
Adolescents and young adults (AYA) with acute lymphoblastic leukaemia (ALL) constitute a distinct population from children and older adults. Based on patterns of referral, they may be treated by either paediatric or adult oncologists. As a group, AYA with ALL have a worse survival and event-free survival (EFS) compared to that achieved by younger children. A systematic review of all published clinical trials, which provide data on treatment and outcome of adolescents with ALL, has been summarised in an effort to determine whether they should be treated on paediatric or adult type protocols. Adolescents appear to have a consistent survival advantage when treated on paediatric regimens. Pediatric Blood Cancer 2006;47:748–756.Keywords
This publication has 44 references indexed in Scilit:
- Use of paediatric versus adult oncology treatment centres by adolescents 15–19 years old: the Canadian Childhood Cancer Surveillance and Control ProgramEuropean Journal of Cancer, 2005
- A comparison of self‐reported satisfaction between adolescents treated in a “teenage” unit with those treated in adult or paediatric unitsPediatric Blood & Cancer, 2004
- Death during induction therapy and first remission of acute leukemia in childhoodCancer, 2004
- Childhood and Adolescent Lymphoid and Myeloid LeukemiaHematology, 2004
- Differences in Outcome in Adolescents With Acute Lymphoblastic Leukemia: A Consequence of Better Regimens? Better Doctors? Both?Journal of Clinical Oncology, 2003
- Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Acute Lymphoblastic Leukemia Studies, 1982–1995Leukemia, 2000
- Long-term results of large prospective trials in childhood acute lymphoblastic leukemiaLeukemia, 2000
- #50 Adolescent cancers in the United StatesJournal of Pediatric Hematology/Oncology, 1999
- Duration and intensity of maintenance chemotherapy in acute lymphoblastic leukaemia: overview of 42 trials involving 12 000 randomised childrenThe Lancet, 1996
- Therapeutic adherence to oral medication regimens by adolescents with cancer. II. Clinical and psychologic correlatesThe Journal of Pediatrics, 1992