In vitro cytotoxicity testing of neodymium‐iron‐boron magnets
- 1 March 1995
- journal article
- Published by Wiley in Journal of Applied Biomaterials
- Vol. 6 (1), 69-74
- https://doi.org/10.1002/jab.770060110
Abstract
Neodymium‐iron‐boron magnets are being increasingly used in orthodontic and orthopedic appliances. The purpose of this study was to investigate the in vitro cytotoxicity of these new “super” magnets. A modified agar overlay technique was performed using both L929 mouse fibroblasts and adult human oral mucosal fibroblasts. The neodyium‐iron‐boron magnets were tested in the following forms: uncoated magnetized, uncoated demagnetized, parylene coated demagnetized, and parylene coated magnetized. Results revealed that uncoated magnetized, uncoated demagnetized, and parylene coated magnetized were cytotoxic to both L929 mouse fibroblasts and human oral mucosal fibroblasts. However the parylene coated demagnetized neodymium magnets were only cytotoxic to the human mucosal fibroblasts. This study supports the hypothesis that these are cytotoxic effects of possibly corrosion products and of magnetism. The specific toxic effects of parylene were not examined in this present study. Statistical analysis (Mann‐Whitney U‐test, p = 0.014) suggested that, in this experiment, the human oral mucosal fibroblasts were more sensitive to the effects of these rare earth magnets. With the evidence of a biological effect, the use of implanted magnets must at present be limited until the safety can be assured. © 1995 John Wiley & Sons, Inc.Keywords
This publication has 20 references indexed in Scilit:
- Orthodontic magnets: effects on gingival epithelium and alveolar bone in monkeysEuropean Journal of Orthodontics, 1992
- Rare earth magnets and impactionAmerican Journal of Orthodontics and Dentofacial Orthopedics, 1991
- Unerupted Premolars—An Alternative ApproachJournal of Orthodontics, 1991
- Magnets and OrthodonticsJournal of Orthodontics, 1989
- Agar overlay methodInternational Endodontic Journal, 1988
- Powerful New Magnet Material FoundScience, 1984
- The use of magnets in orthodontics: an alternative means to produce tooth movementEuropean Journal of Orthodontics, 1984
- Studies on the Sm-Co Magnet as a Dental MaterialJournal of Dental Research, 1979
- Magnetic force in orthodonticsAmerican Journal of Orthodontics, 1978
- The implantation of magnets in the jaw to aid denture retentionThe Journal of Prosthetic Dentistry, 1960