Somatomedin-C Mediates Growth Hormone Negative Feedback by Effects on Both the Hypothalamus and the Pituitary
- 12 June 1981
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 212 (4500), 1279-1281
- https://doi.org/10.1126/science.6262917
Abstract
Somatomedin-C stimulates somatostatin release to a maximum of 390 percent of basal release during short-term (20-minute) incubation of rat hypothalamus. It has no effect on basal or stimulated growth hormone release from primary cultures of rat adenohypophyseal cells during a 4-hour incubation, but inhibits stimulated release by more that 90 percent after 24 hours. These findings suggest that somatomedin-C participates in the growth hormone negative feedback loop with an immediate effect on hypothalamic somatostatin and a delayed effect on the anterior pituitary.This publication has 12 references indexed in Scilit:
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