A serological assay to detect SARS-CoV-2 seroconversion in humans
Top Cited Papers
- 12 May 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Medicine
- Vol. 26 (7), 1033-1036
- https://doi.org/10.1038/s41591-020-0913-5
Abstract
Here, we describe a serological enzyme-linked immunosorbent assay for the screening and identification of human SARS-CoV-2 seroconverters. This assay does not require the handling of infectious virus, can be adjusted to detect different antibody types in serum and plasma and is amenable to scaling. Serological assays are of critical importance to help define previous exposure to SARS-CoV-2 in populations, identify highly reactive human donors for convalescent plasma therapy and investigate correlates of protection.Keywords
Funding Information
- U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (HHSN272201400008C, 75N93019C00051)
- U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases
- Department of Health | National Health and Medical Research Council (1071916, 1102792)
- Academy of Finland (TYH2018322)
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