Malignancy Is Associated with Dermatomyositis But Not Polymyositis in Northern New England, USA
- 16 November 2009
- journal article
- Published by The Journal of Rheumatology in The Journal of Rheumatology
- Vol. 36 (12), 2704-2710
- https://doi.org/10.3899/jrheum.090549
Abstract
Objective.: To retrospectively evaluate the association of idiopathic inflammatory myopathy (IIM) and malignancy in patients seen at 1 academic center over a 23-year period.Methods.: Patients were identified using the International Classification of Diseases, 9th edition (ICD-9) codes and diagnoses, then confirmed by chart review. Population cancer statistics obtained from the US Centers for Disease Control for Vermont and New Hampshire were used for comparison.Results.: Chart review confirmed IIM in 198 of 483 patients initially identified by ICD-9 codes. Within 5 years of diagnosis with IIM, malignancy developed in 32 patients (16.2%), 24 of whom (75%) had dermatomyositis (DM). Malignancy and DM developed within 1 year in 75%. The cancer risk associated with DM was much greater than the risk associated with other IIM. The most frequent tumor types were breast, lung, pancreas, and colon. DM patients with cancer were more frequently male and ≥ 45 years of age than those without cancer. There were no cases of interstitial lung disease among patients with cancer and any form of IIM. The incidence of cancer was increased in patients with DM compared to age- and sex-matched population controls, both over a 5-year interval surrounding the diagnosis of DM and over the lifetime interval following diagnosis.Conclusion.: The risk of cancer in IIM is concentrated among patients with DM. The association between DM and cancer was enhanced by its temporal relationship (< 1 year) in 87.5% of these cases. Patients with malignancy-associated DM were more frequently male and over age 45 and less likely to have interstitial lung disease.Keywords
This publication has 35 references indexed in Scilit:
- The diagnostic utility of myositis autoantibody testing for predicting the risk of cancer-associated myositisAnnals Of The Rheumatic Diseases, 2007
- PolymyositisNeurology, 2003
- Cancer risk following polymyositis and dermatomyositis: a nationwide cohort study in DenmarkCancer Causes & Control, 1995
- Childhood polymyositis as a paraneoplastic phenomenonPediatric Neurology, 1993
- Confidence Intervals for the Mean of a Poisson Distribution: A ReviewBiometrical Journal, 1993
- Amyopathic Dermatomyositis: A Review.Journal of Investigative Dermatology, 1993
- Risk of Cancer in Patients with Dermatomyositis or PolymyositisNew England Journal of Medicine, 1992
- Dermatomyositis and MalignancyDermatology, 1990
- Polymyositis-Dermatomyositis and Malignant Lesions: Does an Association Exist?Mayo Clinic Proceedings, 1986
- Inclusion body myositisNeurology, 1978