No Evidence for Lateral Asymmetry of Neurotransmitters in Post‐Mortem Human Brain

Abstract
Post-mortem studies of human brain tissue provide evidence of biochemical abnormalities in various neurological and psychiatric disorders. Post-mortem human brain was studied to establish whether there is evidence for lateral asymmetry of neurotransmitters. Choline acetyltransferase, glutamic acid decarboxylase, .alpha.-aminobutyric acid, dopamine and noradrenaline [norepinephrine] were measured in 9 comparable areas from the left and right hemispheres of normal post-mortem human brain. Only nigral GABA showed a left-right difference at a 5% significance level. Chemical laterality is unlikely to be an important source of error in human post-morten studies.