Protective effect of drugs on bronchoconstriction induced by sulphur dioxide.
- 1 September 1982
- Vol. 37 (9), 671-675
- https://doi.org/10.1136/thx.37.9.671
Abstract
The response to inhaled sulphur dioxide in eight normal, seven atopic, and 22 asthmatic subjects was studied by measuring thoracic gas volume and airway resistance in a whole-body plethysmograph. The fall in specific airway conductance in relation to the concentration of sulphur dioxide inhaled (0-20 ppm) was determined in all three groups. The specific airway conductance fell significantly in the atopic and asthmatic subjects but not in the normal group. In a double-blind study prior inhalation of disodium cromoglycate caused a significant reduction in the response to sulphur dioxide inhalation in atopic and asthmatic subjects. Prior treatment with inhaled ipratropium bromide blocked the response in the atopic subjects, but the effect was variable in the patients with asthma. Previous treatment with inhaled clemastine also reduced the response in patients with asthma, without causing a change in baseline specific conductance. We conclude that non-allergic bronchial hyperreactivity was increased in the atopic and the asthmatic subjects and that mediator release, in addition to a vagal reflex, has a role in such bronchoconstriction.This publication has 13 references indexed in Scilit:
- ROLE OF BRONCHIAL IRRITANT RECEPTORS IN ASTHMAThe Lancet, 1981
- THE EFFECTS OF SODIUM CROMOGLYCATE ON LUNG IRRITANT RECEPTORS AND LEFT VENTRICULAR CARDIAC RECEPTORS IN THE ANAESTHETIZED DOGBritish Journal of Pharmacology, 1979
- Sodium cromoglycate-induced changes in the dose-response curve of inhaled methacholine and histamine in asthmatic children.Published by Elsevier BV ,1979
- The nature of the receptor mediating stimulant effects of histamine on rapidly adapting vagal afferents in the lungs.Journal Of Physiology-London, 1979
- Bronchial reactivity: interaction between vagal stimulation and inhaled histamineJournal of Applied Physiology, 1977
- Airway response to carbachol in normal and asthmatic subjects: distinction between bronchial sensitivity and reactivity.Published by Elsevier BV ,1977
- Bronchial reactivity to inhaled histamine: a method and clinical surveyClinical & Experimental Allergy, 1977
- The effect of thymoxamine and cromolyn sodium on postexercise bronchoconstriction in asthmaJournal of Allergy and Clinical Immunology, 1976
- Stimulation of lung irritant receptors by cigarette smoke, carbon dust, and histamine aerosol.Journal of Applied Physiology, 1971
- Mode of action of disodium cromoglycate, studies on immediate type hypersensitivity reactions using 'double sensitization' with two antigenically distinct rat reagins.1970