MOLECULAR PROGNOSTICS FOR UVEAL MELANOMA
- 1 February 2018
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Retina
- Vol. 38 (2), 211-219
- https://doi.org/10.1097/iae.0000000000001757
Abstract
To review laboratory methods, currently available commercial tests, caveats and clinical tips regarding prognostic analysis of uveal melanoma tissue. A review of the literature was performed focused on the genetic abnormalities found in uveal melanoma cells, their correlation to the development of metastases, the validity of various laboratory approaches in their detection, and the existing commercially available tests for uveal melanoma prognostication. Numerous laboratory methods exist for analyzing genetic material obtained from uveal melanoma cells. Older tests have been gradually replaced with contemporary methods that are simpler with greater accuracy. Two commercially available assays exist which have not been directly compared—a gene expression profiling test has been validated directly through a large, prospective multicenter study and a DNA-based test which uses laboratory methods supported by extensive historical data. There are myriad laboratory methods for prognostic analysis of uveal melanoma tissue. These tests were historically only available to those with access to an outfitted laboratory. Newer commercially available assays have increased the accessibility of prognostic biopsy for uveal melanoma. The various caveats that exist when considering and performing prognostic biopsy of uveal melanoma are discussed.Keywords
This publication has 94 references indexed in Scilit:
- Genomic Profile of 320 Uveal Melanoma Cases: Chromosome 8p-Loss and Metastatic OutcomeInvestigative Opthalmology & Visual Science, 2013
- The DecisionDx-UM Gene Expression Profile Test Provides Risk Stratification and Individualized Patient Care in Uveal MelanomaPLoS Currents, 2013
- Prognostic significance of chromosome 3 alterations determined by microsatellite analysis in uveal melanoma: a long-term follow-up studyBritish Journal of Cancer, 2012
- Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancersJournal of Medical Genetics, 2011
- Mutations inGNA11in Uveal MelanomaNew England Journal of Medicine, 2010
- Reconciling the principle of patient autonomy with the practice of informed consent: decision-making about prognostication in uveal melanomaHealth Expectations, 2010
- An Accurate, Clinically Feasible Multi-Gene Expression Assay for Predicting Metastasis in Uveal MelanomaThe Journal of Molecular Diagnostics, 2010
- Loss of Heterozygosity of Chromosome 3 Detected with Single Nucleotide Polymorphisms Is Superior to Monosomy 3 for Predicting Metastasis in Uveal MelanomaClinical Cancer Research, 2007
- Tumor doubling times in metastatic malignant melanoma of the uvea Tumor progression before and after treatmentOphthalmology, 2000
- The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma II: initial mortality findings COMS report no. 10American Journal of Ophthalmology, 1998