Haptoglobin: Basic and Clinical Aspects
Top Cited Papers
- 15 January 2010
- journal article
- review article
- Published by Mary Ann Liebert Inc in Antioxidants and Redox Signaling
- Vol. 12 (2), 293-304
- https://doi.org/10.1089/ars.2009.2793
Abstract
Haptoglobin is an abundant hemoglobin-binding protein present in the plasma. The function of haptoglobin is primarily to determine the fate of hemoglobin released from red blood cells after either intravascular or extravascular hemolysis. There are two common alleles at the Hp genetic locus denoted 1 and 2. There are functional differences between the Hp 1 and Hp 2 protein products in protecting against hemoglobin-driven oxidative stress that appear to have important clinical significance. In particular, individuals with the Hp 2-2 genotype and diabetes mellitus appear to be at significantly higher risk of microvascular and macrovascular complications. A pharmacogenomic strategy of administering high dose antioxidants specifically to Hp 2-2 DM individuals may be clinically effective. Antioxid. Redox Signal. 12, 293–304.Keywords
This publication has 59 references indexed in Scilit:
- Hemoglobin and Its Scavenger Protein Haptoglobin Associate with ApoA-1-containing Particles and Influence the Inflammatory Properties and Function of High Density LipoproteinOnline Journal of Public Health Informatics, 2009
- Coronary Intraplaque Hemorrhage Evokes a Novel Atheroprotective Macrophage PhenotypeThe American Journal of Pathology, 2009
- Correction of HDL Dysfunction in Individuals With Diabetes and the Haptoglobin 2-2 GenotypeDiabetes, 2008
- Rate of nitric oxide scavenging by hemoglobin bound to haptoglobinNitric Oxide, 2008
- Vitamin E Supplementation Reduces Cardiovascular Events in a Subgroup of Middle-Aged Individuals With Both Type 2 Diabetes Mellitus and the Haptoglobin 2-2 GenotypeArteriosclerosis, Thrombosis, and Vascular Biology, 2008
- Haptoglobin 2-2 Genotype Determines Chronic Vasospasm After Experimental Subarachnoid HemorrhageStroke, 2007
- Seasonal Childhood Anaemia in West Africa Is Associated with the Haptoglobin 2-2 GenotypePLoS Medicine, 2006
- Genetically Determined Heterogeneity in Hemoglobin Scavenging and Susceptibility to Diabetic Cardiovascular DiseaseCirculation Research, 2003
- Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysisBlood, 2002
- Structure and assembly of haptoglobin polymers by electron microscopyJournal of Molecular Biology, 1984