Methyl methacrylate concentrations in tissues adjacent to bone cement
- 1 July 1980
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 14 (4), 427-434
- https://doi.org/10.1002/jbm.820140409
Abstract
The amount of methyl methacrylate monomer present in bone tissue immediately adjacent to implanted bone cement that has polymerized in vivo has been determined. Poly(methyl methacrylate) was implanted into the distal femoral condyle of the dog and allowed to polymerize. At various times following polymerization, samples were removed and sections adjacent to the cement were cut and subjected to homogenization followed by liquid gas chromatographic determination of the amount of methyl methacrylate monomer present. The highest concentration of methyl methacrylate monomer present in bone tissue was 0.140% in the 1000 μm of bone tissue adjacent to bone cement immediately after polymerization of the cement. The concentration was very similar (0.137%) 1 hr after cement polymerization, but dropped off rapidly following that with no free methyl methacrylate monomer present in bone tissue adjacent to cement after 4 hr following cement polymerization.Keywords
This publication has 13 references indexed in Scilit:
- Influence of methyl methacrylate on quantitative gel diffusion assay of immunoglobulinsJournal of Biomedical Materials Research, 1979
- Monomer release from methacrylate bone cements during simulated in vivo polymerizationJournal of Biomedical Materials Research, 1979
- Effect of simplex liquid methyl methacrylate monomer on cellsJournal of Biomedical Materials Research, 1978
- The effect of methylmethacrylate on bacterial phagocytosis and killing by human polymorphonuclear leukocytes.The Journal of Bone & Joint Surgery, 1978
- The effect of methylmethacrylate on chemotaxis of polymorphonuclear leukocytes.The Journal of Bone & Joint Surgery, 1978
- Reaction of bone to the acute chemical trauma of bone cementThe Journal of Bone & Joint Surgery, 1977
- Tissue Reactin to Methyl Methacrylate Monomer:A Comparative Study in the Rabbit's Ear on the Toxicity of Methyl Methacrylate Monomer of Varying CompositionActa Orthopaedica, 1976
- Complications of total hip arthroplasty treated by reoperationThe Journal of Bone & Joint Surgery, 1975
- Circulatory Depression in Bone after Acrylic ImplantationClinical Orthopaedics and Related Research, 1975
- Blood Clearance and Acute Pulmonary Toxicity of Methylmethacrylate in Dogs after Simulated Arthroplasty and Intravenous InjectionThe Journal of Bone & Joint Surgery, 1973