Bacitracin Versus Mupirocin for Staphylococcus aureus Nasal Colonization
- 1 May 1999
- journal article
- research article
- Published by Cambridge University Press (CUP) in Infection Control & Hospital Epidemiology
- Vol. 20 (5), 351-353
- https://doi.org/10.1086/501633
Abstract
We performed a randomized prospective study of 5-day treatment with topical mupirocin or bacitracin for the elimination ofStaphylococcus aureusnasal colonization in healthcare workers (HCWs). Nasal cultures were obtained from 141 HCWs, 37 (26%) of whom showed Saureus.After 72 to 96 hours of treatment, the organism was eradicated in 15 (94%) of 16 by mupirocin and in 8 (44%) of 18 by bacitracin (P=.0031). Similar efficacy was demonstrated at 30 days. Mupirocin may be more effective than bacitracin for eradication of Saureusin healthy HCWs.Keywords
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