Neuropsychological Assessment of Dementia
- 1 January 2009
- journal article
- review article
- Published by Annual Reviews in Annual Review of Psychology
- Vol. 60 (1), 257-282
- https://doi.org/10.1146/annurev.psych.57.102904.190024
Abstract
Neuropsychological studies show that cognitive deficits associated with Alzheimer's disease (AD) are distinct from age-associated cognitive decline. Quantitative and qualitative differences are apparent across many cognitive domains, but are especially obvious in episodic memory (particularly delayed recall), semantic knowledge, and some aspects of executive functions. The qualitatively distinct pattern of deficits is less salient in very old AD patients than in younger AD patients. Although decline in episodic memory is usually the earliest cognitive change that occurs prior to the development of the AD dementia syndrome, asymmetry in cognitive abilities may also occur in this “preclinical” phase of the disease and predict imminent dementia. Discrete patterns of cognitive deficits occur in AD and several neuropathologically distinct age-associated neurodegenerative disorders. Knowledge of these differences helps to clinically distinguish among various causes of dementia and provides useful models for und...This publication has 154 references indexed in Scilit:
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