Circular RNAs and their roles in head and neck cancers
Open Access
- 21 March 2019
- journal article
- review article
- Published by Springer Science and Business Media LLC in Molecular Cancer
- Vol. 18 (1), 1-18
- https://doi.org/10.1186/s12943-019-1003-5
Abstract
Circular RNAs are abundant endogenous non-coding RNA with no 5′ cap and 3′ polyadenylation tail that modify liner mRNAs and have no terminal structures. Our knowledge of the biogenesis of circular RNAs has been expanded, and circular RNAs were shown to be key regulators of various diseases, especially cancers. Head and neck cancers are the sixth most popular cancers worldwide, and the overall survival rates remain unsatisfactory. Recent studies have indicated that circular RNAs are involved in the tumorigenesis, progression, invasion and chemosensitivity of head and neck cancers and that some circular RNAs could serve as diagnostic and prognostic biomarkers. In this study, we summarize research advances in the regulation of circular RNA biogenesis, their characteristics and functions, the involvement of circular RNAs in the pathophysiology of head and neck cancers and their potential clinical utilization, as well as the likely directions of future studies.Keywords
Funding Information
- Science and Technology Commission of Shanghai Municipality (12J1402100, 16411950101)
- Shanghai Shen Kang Hospital Development Center (SHDC12015114)
- National Natural Science Foundation of China (81402237)
This publication has 206 references indexed in Scilit:
- Cell-Type Specific Features of Circular RNA ExpressionPLoS Genetics, 2013
- MicroRNA-196a Is a Putative Diagnostic Biomarker and Therapeutic Target for Laryngeal CancerPLOS ONE, 2013
- Identification of Cancer Stem-Like Side Population Cells in Purified Primary Cultured Human Laryngeal Squamous Cell Carcinoma EpitheliaPLOS ONE, 2013
- Circular RNAs are abundant, conserved, and associated with ALU repeatsRNA, 2012
- Landscape of transcription in human cellsNature, 2012
- Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell TypesPLOS ONE, 2012
- miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNAThe EMBO Journal, 2011
- BMI1'S maintenance of the proliferative capacity of laryngeal cancer stem cellsHead & Neck, 2010
- In vivo investigation of CD133 as a putative marker of cancer stem cells in Hep‐2 cell lineHead & Neck, 2008
- Isolation and characterization of Sendai virus DI-RNAsCell, 1976