Hydroxymatairesinol, a Novel Enterolactone Precursor With Antitumor Properties From Coniferous Tree (Picea abies)
- 1 March 2000
- journal article
- Published by Informa UK Limited in Nutrition and Cancer
- Vol. 36 (2), 207-216
- https://doi.org/10.1207/s15327914nc3602_10
Abstract
The potential for the extraction of the plant lignan hydroxymatairesinol (HMR) in large scale from Norway spruce (Picea abies) has given us the opportunity to study the metabolism and biological actions of HMR in animals. HMR, the most abundant single component of spruce lignans, was metabolized to enterolactone (ENL) as the major metabolite in rats after oral administration. The amounts of urinary ENL increased with the dose of HMR (from 3 to 50 mg/kg), and only minor amounts of unmetabolized HMR isomers and other lignans were found in urine. HMR (15 mg/kg body wt po) given for 51 days decreased the number of growing tumors and increased the proportion of regressing and stabilized tumors in the rat dimethylbenz[a]anthracene-induced mammary tumor model. HMR (50 mg/kg body wt) did not exert estrogenic or antiestrogenic activity in the uterine growth test in immature rats. HMR also showed no antiandrogenic responses in the growth of accessory sex glands in adult male rats. Neither ENL nor enterodiol showed estrogenic or antiestrogenic activity via a classical alpha- or beta-type estrogen receptor-mediated pathway in vitro at < 1.0 microM. HMR was an effective antioxidant in vitro.Keywords
This publication has 28 references indexed in Scilit:
- Inhibitory effects of soy and rye diets on the development of Dunning R3327 prostate adenocarcinoma in ratsThe Prostate, 1998
- Case-control study of phyto-oestrogens and breast cancerThe Lancet, 1997
- Soy and rye diets inhibit the development of Dunning R3327 prostatic adenocarcinoma in ratsCancer Letters, 1997
- SHORT COMMUNICATION: Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesisCarcinogenesis: Integrative Cancer Research, 1996
- The influence of flaxseed and lignans on colon carcinogenesis and β-glucuronidase activityCarcinogenesis: Integrative Cancer Research, 1996
- Antitumorigenic effect of a mammalian lignan precursor from flaxseedNutrition and Cancer, 1996
- The effect of flaxseed supplementation on the initiation and promotional stages of mammary tumorigenesisNutrition and Cancer, 1992
- The effect of flaxseed supplementation on early risk markers for mammary carcinogenesisCancer Letters, 1991
- Origin of lignans in mammals and identification of a precursor from plantsNature, 1982
- The excretion of lignans in rats — evidence for an intestinal bacterial source for this new group of compoundsFEBS Letters, 1981