Disparities in Infant Mortality: What’s Genetics Got to Do With It?
- 1 July 2007
- journal article
- Published by American Public Health Association in American Journal of Public Health
- Vol. 97 (7), 1191-1197
- https://doi.org/10.2105/ajph.2005.068387
Abstract
Since 1950, dramatic advances in human genetics have occurred, racial disparities in infant mortality have widened, and the United States’ international ranking in infant mortality has deteriorated. The quest for a “preterm birth gene” to explain racial differences is now under way. Scores of papers linking polymorphisms to preterm birth have appeared in the past few years. Is this strategy likely to reduce racial disparities? We reviewed broad epidemiological patterns that call this approach into question. Overall patterns of racial disparities in mortality and secular changes in rates of prematurity as well as birth-weight patterns in infants of African immigrant populations contradict the genetic theory of race and point toward social mechanisms. We postulate that a causal link to class disparities in health exists.Keywords
This publication has 77 references indexed in Scilit:
- Genetic Variation in the Sodium-dependent Vitamin C Transporters, SLC23A1, and SLC23A2 and Risk for Preterm DeliveryAmerican Journal of Epidemiology, 2005
- Current understanding of genetic factors in preterm birthBJOG: An International Journal of Obstetrics and Gynaecology, 2005
- A single nucleotide A>G polymorphism at position −670 in the Fas gene promoter: Relationship to preterm premature rupture of fetal membranes in multifetal pregnanciesAmerican Journal of Obstetrics and Gynecology, 2005
- Fetal interleukin-1 receptor antagonist gene polymorphism, intra-amniotic interleukin-1β levels, and history of spontaneous abortionAmerican Journal of Obstetrics and Gynecology, 2004
- Adverse outcomes after preterm labor are associated with tumor necrosis factor-α polymorphism −863, but not −308, in mother-infant pairsAmerican Journal of Obstetrics and Gynecology, 2004
- Social determinants for infant mortality in the Nordic countries, 1980 - 2001Scandinavian Journal of Public Health, 2004
- Thrombophilic polymorphisms – factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations – and preterm birthWiener klinische Wochenschrift, 2004
- Interleukin-4 and -10 gene polymorphisms and spontaneous preterm birth in multifetal gestationsAmerican Journal of Obstetrics and Gynecology, 2004
- Polymorphism in intron 2 of the fetal interleukin-1 receptor antagonist genotype influences midtrimester amniotic fluid concentrations of interleukin-1β and interleukin-1 receptor antagonist and pregnancy outcomeAmerican Journal of Obstetrics and Gynecology, 2003
- Genetic Structure of Human PopulationsScience, 2002