Retromer: A Master Conductor of Endosome Sorting
Top Cited Papers
- 1 February 2014
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Perspectives in Biology
- Vol. 6 (2), a016774
- https://doi.org/10.1101/cshperspect.a016774
Abstract
The endosomal network comprises an interconnected network of membranous compartments whose primary function is to receive, dissociate, and sort cargo that originates from the plasma membrane and the biosynthetic pathway. A major challenge in cell biology is to achieve a thorough molecular description of how this network operates, and in so doing, how defects contribute to the etiology and pathology of human disease. We discuss the increasing body of evidence that implicates an ancient evolutionary conserved complex, termed “retromer,” as a master conductor in the complex orchestration of multiple cargo-sorting events within the endosomal network.Keywords
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