D‐serine in the developing human central nervous system
- 26 October 2006
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 60 (4), 476-480
- https://doi.org/10.1002/ana.20977
Abstract
To elucidate the role of D-serine in human central nervous system, we analyzed D-serine, L-serine, and glycine concentrations in cerebrospinal fluid of healthy children and children with a defective L-serine biosynthesis (3-phosphoglycerate dehydrogenase deficiency). Healthy children showed high D-serine concentrations immediately after birth, both absolutely and relative to glycine and L-serine, declining to low values at infancy. D-Serine concentrations were almost undetectable in untreated 3-phosphoglycerate dehydrogenase–deficient patients. In one patient treated prenatally, D-serine concentration was nearly normal at birth and the clinical phenotype was normal. These observations suggest a pivotal role for D-serine in normal and aberrant human brain development. Ann Neurol 2006;60:476–480This publication has 22 references indexed in Scilit:
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