Axonal Damage But No Increased Glial Cell Activity in the Normal-Appearing White Matter of Patients with Clinically Isolated Syndromes Suggestive of Multiple Sclerosis Using High-Field Magnetic Resonance Spectroscopy
Open Access
- 1 September 2007
- journal article
- Published by American Society of Neuroradiology (ASNR) in American Journal of Neuroradiology
- Vol. 28 (8), 1517-1522
- https://doi.org/10.3174/ajnr.a0594
Abstract
BACKGROUND AND PURPOSE: Proton MR spectroscopy (1H-MR spectroscopy) is a well-established method for the in vivo investigation of the normal-appearing white matter (NAWM) in patients with multiple sclerosis (MS). Metabolic changes in NAWM are of special interest in patients with clinically isolated syndromes (CIS) suggestive of MS regarding further prognostic classifications. The purpose of this study was to investigate metabolic alterations in NAWM in patients with CIS with use of high-field 1H-MR spectroscopy and to compare the results to those in patients with an early course of MS.Keywords
This publication has 36 references indexed in Scilit:
- MRI T2 lesion burden in multiple sclerosisNeurology, 2006
- MR spectroscopic evidence for thalamic and hippocampal, but not cortical, damage in multiple sclerosisMagnetic Resonance in Medicine, 2006
- Relapsing-Remitting Multiple Sclerosis: Metabolic Abnormality in Nonenhancing Lesions and Normal-appearing White Matter at MR Imaging: Initial ExperienceRadiology, 2005
- Infratentorial Lesions Predict Long-term Disability in Patients With Initial Findings Suggestive of Multiple SclerosisArchives of Neurology, 2004
- Magnetic resonance studies of abnormalities in the normal appearing white matter and grey matter in multiple sclerosisZeitschrift für Neurologie, 2003
- Validation of diagnostic magnetic resonance imaging criteria for multiple sclerosis and response to interferon β1aAnnals of Neurology, 2003
- Measurement of regional N‐Acetylaspartate after transient global ischemia in gerbils with and without ischemic tolerance: An index of neuronal survivalAnnals of Neurology, 1998
- Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosisBrain, 1997
- Multinuclear NMR Studies on the Energy Metabolism of Glial and Neuronal CellsDevelopmental Neuroscience, 1993
- Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodiesNeuroscience, 1991