Designing CD4 immunoadhesins for AIDS therapy
- 1 February 1989
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 337 (6207), 525-531
- https://doi.org/10.1038/337525a0
Abstract
A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic useKeywords
This publication has 48 references indexed in Scilit:
- Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: Effect of HIV sequence variation and a mechanism for CD4+ cell depletionCell, 1988
- Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptorCell, 1987
- The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brainCell, 1986
- Shedding and Interspecies Type Sero-reactivity of the Envelope Glycopolypeptide gp120 of the Human Immunodeficiency VirusJournal of General Virology, 1986
- Man versus Beast: Pharmacokinetic Scaling in MammalsJournal of Pharmaceutical Sciences, 1986
- Immunoglobulin flexibility in complement activationImmunology Today, 1986
- Binding of HTLV-III/LAV to T4 + T Cells by a Complex of the 110K Viral Protein and the T4 MoleculeScience, 1986
- T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAVNature, 1984
- The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirusNature, 1984
- Binding of complement subcomponent Clq to mouse IgGl, IgG2a AND IgG2b: A novel Clq binding assayMolecular Immunology, 1984