Progressive Deterioration of Intellect and Motor Function Occurring Several Decades After Cranial Irradiation
- 1 August 1996
- journal article
- case report
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 53 (8), 814-818
- https://doi.org/10.1001/archneur.1996.00550080140022
Abstract
Objective: To report the cases of 2 patients who developed the features of radiation encephalopathy 33 and 28 years after cranial irradiation. Design: Case reports; clinical data were available for 2 years in each instance. Conclusion: Latent intervals approaching 2 decades have been reported in cases of radiation necrosis following cranial irradiation, but a similar or greater delay before the onset of radiation encephalopathy has not been described previously. This report indicates that a diagnosis of radiation encephalopathy must be considered when any individual who has received cranial irradiation presents with deterioration in intellectual or motor function, whatever the interval.Keywords
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