Autoreaktive Urtikaria und Autoimmunurtikaria
- 1 April 2004
- journal article
- research article
- Published by Springer Science and Business Media LLC in Die Dermatologie
- Vol. 55 (4), 350-356
- https://doi.org/10.1007/s00105-004-0692-9
Abstract
Die autoreaktive Urtikaria (ArU) ist eine Form der chronischen Urtikaria (CU), deren Symptome durch mastzellaktivierende Serumbestandteile verursacht werden. Sie lässt sich mit Hilfe des autologen Serumtests einfach, rasch und sicher diagnostizieren. Bei einem Teil der ArU-Patienten sind funktionelle Autoantikörper gegen IgE oder dessen Rezeptor FcεRI und damit eine Autoimmunurtikaria (AiU) nachweisbar. ArU- und AiU-Patienten weisen klinische und laborchemische Unterschiede zu anderen CU-Patienten auf. Symptoms in patients with autoreactive urticaria (ArU), a sub-form of chronic urticaria (CU), are caused by circulating histamine−releasing signals. ArU patients are readily identified by the autologous serum skin test, in which they exhibit inflammatory reactions to their serum after intracutaneous injection. CU patients who also exhibit functional autoantibodies against IgE and/or its high affinity receptor FcεRI are thought to suffer from autoimmune urticaria (Aiu). ArU and AiU are pathogenetically and clinically different from other sub-forms of CU.Keywords
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