The association of serum metabolites with clinical disease during the transition period
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- 1 October 2011
- journal article
- Published by American Dairy Science Association in Journal of Dairy Science
- Vol. 94 (10), 4897-4903
- https://doi.org/10.3168/jds.2010-4075
Abstract
The objective of this observational field study was to validate the relationship of serum concentrations of nonesterified fatty acids (NEFA), β-hydroxybutyrate (BHBA), and calcium with disease in early lactation across different management systems. Fifty-five Holstein freestall dairy herds located across the United States and Canada were selected and visited weekly for blood sample collection from 2,365 cows. Only diseases that were consistently recorded across herds and blood samples collected before the disease occurred were considered. Metabolite concentrations in serum in wk -1 relative to calving were considered as predictors of retained placenta (RP) and metritis, and metabolite concentrations in serum in wk -1 and wk +1 relative to calving were considered as predictors of displaced abomasum (DA). For each disease, each metabolite, and week of sampling in the case of DA, a critical threshold was calculated based on the highest combined sensitivity and specificity and used to categorize the serum concentrations into high and low risk categories. Multivariable logistic regression models were built for each disease of interest and week of sampling, considering cow as the experimental unit and herd as a random effect. Cows with precalving serum NEFA concentrations ≥ 0.3 mEq/L were more likely to develop RP [odds ratio (OR) = 1.8; 95% confidence interval (CI) = 1.3 to 2.6] and metritis (OR = 1.8; 95% CI = 1.5 to 2.9) after calving than cows with lower NEFA concentrations. Precalving NEFA ≥ 0.5 mEq/L (OR = 2.4; 95% CI = 1.5 to 3.7), postcalving NEFA ≥ 1.0 mEq/L (OR = 2.7; 95% CI = 1.7 to 4.4), and postcalving calcium ≤ 2.2 mmol/L (OR = 3.1; 95% CI = 1.9 to 5.0) were associated with subsequent risk of DA. In conclusion, elevated serum NEFA concentrations within 1 wk before calving were associated with increased risk of RP, metritis, and DA after calving. Serum NEFA and calcium concentrations in the 2 wk around calving in combination were associated with the risk of DA.Keywords
This publication has 22 references indexed in Scilit:
- Prepartum feeding behavior is an early indicator of subclinical ketosisJournal of Dairy Science, 2009
- Impact of hyperketonemia in early lactation dairy cows on health and productionJournal of Dairy Science, 2009
- Prepartum Behavior and Dry Matter Intake Identify Dairy Cows at Risk for MetritisJournal of Dairy Science, 2007
- Neutrophil function and energy status in Holstein cows with uterine health disordersVeterinary Immunology and Immunopathology, 2006
- Evaluation and Use of Three Cowside Tests for Detection of Subclinical Ketosis in Early Postpartum CowsJournal of Dairy Science, 2004
- Animal and Dietary Factors Affecting Feed Intake During the Prefresh Transition Period in HolsteinsJournal of Dairy Science, 2002
- Ruminant Adaptation to Negative Energy BalanceVeterinary Clinics of North America: Food Animal Practice, 2000
- Dry Cow Diet, Management, and Energy Balance as Risk Factors for Displaced Abomasum in High Producing Dairy HerdsJournal of Dairy Science, 1998
- Partitioning of Nutrients During Pregnancy and Lactation: A Review of Mechanisms Involving Homeostasis and HomeorhesisJournal of Dairy Science, 1980
- Effect of Dry Period Overconditioning on Subsequent Metabolic Disorders and Performance of Dairy CowsJournal of Dairy Science, 1980