A Role for PPARin the Regulation of Cytokines in Immune Cells and Cancer
Open Access
- 12 June 2008
- journal article
- review article
- Published by Hindawi Limited in PPAR Research
- Vol. 2008, 1-12
- https://doi.org/10.1155/2008/961753
Abstract
Peroxisome proliferator-activated receptor(PPAR) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. PPARand its ligands appear to serve diverse biological functions. In addition to the well-studied effects of PPARon metabolism and cellular differentiation, abundant evidence suggests that PPARis an important regulator of the immune system and cancers. Since cytokines are not only key modulators of inflammation with pro- and anti-inflammatory functions but they also can either stimulate or inhibit tumor growth and progression, this review summarizes the role for PPARin the regulation of cytokine production and cytokine-mediated signal transduction pathways in immune cells and cancer.
Funding Information
- National Cancer Institute (NO1-CO-12400)
This publication has 117 references indexed in Scilit:
- Th17: the third member of the effector T cell trilogyCurrent Opinion in Immunology, 2007
- Inflammation and cancer: An ancient link with novel potentialsInternational Journal of Cancer, 2007
- PPARs and molecular mechanisms of transrepressionBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2007
- TH-17 cells in the circle of immunity and autoimmunityNature Immunology, 2007
- Antineoplastic effects of peroxisome proliferatoractivated receptor γ agonistsThe Lancet Oncology, 2004
- Interleukin-1 polymorphisms associated with increased risk of gastric cancerNature, 2000
- The Hallmarks of CancerCell, 2000
- Terminal Differentiation of Human Breast Cancer through PPARγMolecular Cell, 1998
- The RXR heterodimers and orphan receptorsCell, 1995
- Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factorCell, 1994