CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma
- 14 November 2013
- journal article
- Published by American Society of Hematology in Blood
- Vol. 122 (20), 3461-3472
- https://doi.org/10.1182/blood-2013-04-493361
Abstract
Key Points T cells genetically targeted to the tumor-promoting antigen CD44v6 are effective against AML and MM. CD44v6-targeted T cells do not recognize hematopoietic stem cells and keratinocytes but cause reversible monocytopenia.Keywords
This publication has 49 references indexed in Scilit:
- Adoptive immunotherapy for cancer: harnessing the T cell responseNature Reviews Immunology, 2012
- Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid LeukemiaThe New England Journal of Medicine, 2011
- CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patientsJCI Insight, 2011
- Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19Blood, 2010
- Lethal graft-versus-host disease in mouse models of T cell receptor gene therapyNature Medicine, 2010
- Treatment of Chronic Lymphocytic Leukemia With Genetically Targeted Autologous T Cells: Case Report of an Unforeseen Adverse Event in a Phase I Clinical TrialMolecular Therapy, 2010
- Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastomaNature Medicine, 2008
- A Phase I Study on Adoptive Immunotherapy Using Gene-Modified T Cells for Ovarian CancerClinical Cancer Research, 2006
- Cancer Regression in Patients After Transfer of Genetically Engineered LymphocytesScience, 2006
- Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.Proceedings of the National Academy of Sciences of the United States of America, 1993