Clinical and genetic associations of autoantibodies to 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme a reductase in patients with immune‐mediated myositis and necrotizing myopathy
- 18 December 2014
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 52 (2), 196-203
- https://doi.org/10.1002/mus.24541
Abstract
Introduction: Inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) with statins may trigger idiopathic inflammatory myositis (IIM) or immune-mediated necrotizing myopathy (IMNM). Anti-HMGCR antibodies have been detected in patients with IIM/IMNM. We aimed to determine the associations of anti-HMGCR in IIM/IMNM. Methods: Anti-HMGCR antibodies were detected by ELISA in sera from patients with IIM/IMNM. Results: Anti-HMGCR antibodies were detected in 19 of 207 patients with IIM/IMNM, and there was a trend toward an association with male gender (P = 0.079). Anti-HMGCR antibodies were associated strongly with statin exposure (OR = 39, P = 0.0001) and HLA-DRB1*11 (OR = 50, P < 0.0001). The highest risk for development of anti-HMGCR antibodies was among HLA-DR11 carriers exposed to statins. Univariate analysis showed a strong association of anti-HMGCR antibodies with diabetes mellitus (P = 0.008), which was not confirmed by multiple regression. Among anti-HMGCR+ patients there was a trend toward increased malignancy (P = 0.15). Conclusions: Anti-HMGCR antibodies are seen in all subtypes of IIM and IMNM and are associated strongly with statin use and HLA-DR11. Muscle Nerve 52: 196–203, 2015Keywords
This publication has 39 references indexed in Scilit:
- Increased frequency of DRB1*11:01 in anti–hydroxymethylglutaryl‐coenzyme A reductase–associated autoimmune myopathyArthritis Care & Research, 2012
- Rarity of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies in statin users, including those with self-limited musculoskeletal side effectsArthritis Care & Research, 2011
- Inflammatory or necrotizing myopathies, myositides and other acquired myopathies, new insight in 2011La Presse Médicale, 2011
- Pathophysiology of inflammatory and autoimmune myopathiesLa Presse Médicale, 2011
- Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathyArthritis & Rheumatism, 2010
- A novel autoantibody recognizing 200‐kd and 100‐kd proteins is associated with an immune‐mediated necrotizing myopathyArthritis & Rheumatism, 2010
- The diagnostic utility of myositis autoantibody testing for predicting the risk of cancer-associated myositisAnnals Of The Rheumatic Diseases, 2007
- Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomesArthritis Research & Therapy, 2007
- HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosisLeukemia, 2002
- Humoral Immunity in Polymyositis/DermatomyositisJournal of Investigative Dermatology, 1993