Ruthenium-Catalyzed (2 + 2) Intramolecular Cycloaddition of Allenenes
- 28 April 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 133 (20), 7660-7663
- https://doi.org/10.1021/ja200784n
Abstract
We report a ruthenium-catalyzed (2 + 2) intramolecular cycloaddition of allenes and alkenes. We have found that the use of the ruthenium complex RuH2Cl2((PPr3)-Pr-i)(2), which has previously gone unnoticed in catalytic applications, is crucial for the observed reactivity. The reaction proceeds under mild conditions and is fully diastereoselective, providing a practical entry to a variety of bicyclo[3.2.0]heptane skeletons featuring cyclobutane rings.Keywords
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