Impaired heart rate variability in euthymic bipolar patients
- 7 April 2003
- journal article
- research article
- Published by Wiley in Bipolar Disorders
- Vol. 5 (2), 138-143
- https://doi.org/10.1034/j.1399-5618.2003.00027.x
Abstract
Background: Power spectral analysis of heart rate variability (HRV) has recently been shown to be a reliable non‐invasive test for quantitative assessment of the central sympathovagal interaction that modulates cardiovascular autonomic function. Methods: We studied 39 euthymic bipolar patients and 39 controls, matched for age and sex. A high‐resolution electrocardiogram was obtained during complete rest. Spectral analysis of R–R intervals was performed by the fast Fourier transform algorithm. Results: Euthymic bipolar patients at rest are characterized by markedly low HRV, independent of specific drug treatments. Conclusion: While these results of autonomic stability in euthymic bipolar patients are counter‐intuitive, the findings may be important in understanding pathophysiology of bipolar affective illness.Keywords
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