Aldose reductase and ϱ‐crystallin belong to the same protein superfamily as aldehyde reductase
- 10 August 1987
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 220 (1), 209-213
- https://doi.org/10.1016/0014-5793(87)80905-5
Abstract
Aldose reductase (EC 1.1.1.21) has been implicated in a variety of diabetic complications. Here we present the first primary sequence data for the rat lens enzyme, obtained by amino acid and cDNA analysis. We have found structural similarities with another NADPH‐dependent oxidoreductase: human liver aldehyde reductase (EC 1.1.1.2). The identity between these two enzymes is 50%. Both enzymes share approx. 40–50% homology with ϱ‐crystallin, a major lens protein present only in the frog, Rana pipiens. We propose that aldose reductase, aldehyde reductase and ϱ‐crystallin are members of a superfamily of related proteins.Keywords
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