The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies
Top Cited Papers
- 25 March 2013
- journal article
- review article
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 44 (4), 673-683
- https://doi.org/10.1017/s0033291713000494
Abstract
BackgroundDementia with Lewy bodies (DLB) is increasingly recognized as a common cause of dementia in older people. However, its true frequency remains unclear, with previous studies reporting a prevalence range from zero to 22.8% of all dementia cases. This review aimed to establish the population prevalence and incidence for DLB and to compare this to its prevalence in secondary care settings.MethodA literature review of all relevant population and clinical studies was conducted using PubMed. Additional references from papers found during that process were added to this.ResultsDLB accounted for 4.2% of all diagnosed dementias in the community. In secondary care this increased to 7.5%. The incidence of DLB was 3.8% of new dementia cases. There was a significant increase in DLB diagnoses when using the revised (2005) International Consensus Criteria (ICC) for DLB compared to the original (1996) criteria.ConclusionsDLB currently accounts for around one in 25 dementia cases diagnosed in the community and one in 13 cases in secondary care. The significantly higher rates of DLB in secondary care may reflect enhanced diagnostic accuracy in specialist settings and/or the increased morbidity and carer burden of the DLB syndrome compared to other dementias. However, the true prevalence is likely to be much higher because DLB diagnoses are often missed, although there is evidence that new criteria aid case identification.Keywords
This publication has 59 references indexed in Scilit:
- Lewy Body DementiaAlzheimer Disease & Associated Disorders, 2010
- Practical suggestions on how to differentiate dementia with Lewy bodies from Alzheimer's disease with common cognitive testsInternational Journal of Geriatric Psychiatry, 2009
- Clinical findings, functional abilities and caregiver distress in the early stage of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD)Archives of Gerontology and Geriatrics, 2009
- High Prevalence of Orthostatic Hypotension in Mild DementiaDementia and Geriatric Cognitive Disorders, 2009
- Prevalence of Dementia in the United States: The Aging, Demographics, and Memory StudyNeuroepidemiology, 2007
- High Prevalence of Dementia in a Caribbean PopulationNeuroepidemiology, 2007
- The protocols for the 10/66 dementia research group population-based research programmeBMC Public Health, 2007
- Frequency and Clinical Characteristics of Early-Onset Dementia in Consecutive Patients in a Memory ClinicDementia and Geriatric Cognitive Disorders, 2007
- Dementia with Lewy bodies according to the consensus criteria in a general population aged 75 years or olderJournal of Neurology, Neurosurgery & Psychiatry, 2003
- The Neuropsychiatric InventoryNeurology, 1994