WNT signalling pathways as therapeutic targets in cancer
Top Cited Papers
- 21 December 2012
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Cancer
- Vol. 13 (1), 11-26
- https://doi.org/10.1038/nrc3419
Abstract
Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.Keywords
This publication has 146 references indexed in Scilit:
- Comprehensive molecular characterization of human colon and rectal cancerNature, 2012
- Frizzled7 as an emerging target for cancer therapyCellular Signalling, 2012
- β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient MelanomasCancer Cell, 2011
- Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the BreastCell, 2011
- A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesisCell Research, 2011
- Wnt Signaling Gradients Establish Planar Cell Polarity by Inducing Vangl2 Phosphorylation through Ror2Developmental Cell, 2011
- Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in CultureCell Stem Cell, 2010
- WNT/TCF Signaling through LEF1 and HOXB9 Mediates Lung Adenocarcinoma MetastasisCell, 2009
- Loss of β-Catenin Impairs the Renewal of Normal and CML Stem Cells In VivoCancer Cell, 2007
- Downregulation of Wnt Signaling Is a Trigger for Formation of Facultative Heterochromatin and Onset of Cell Senescence in Primary Human CellsMolecular Cell, 2007