The Evaluation of Neutrophil-Lymphocyte Ratio in Alzheimer’s Disease
- 1 January 2012
- journal article
- Published by S. Karger AG in Dementia and Geriatric Cognitive Disorders
- Vol. 34 (2), 69-74
- https://doi.org/10.1159/000341583
Abstract
There is growing consensus in the literature that inflammation plays a significant role in the pathophysiology of Alzheimer's disease (AD). The blood neutrophil-lymphocyte ratio (NLR) is a new, inexpensive and easily applicable marker of inflammation. The aim of this study was to investigate the association between NLR, as an inflammatory biomarker, and AD. 241 AD patients and 175 patients with normal cognitive function were evaluated in this study. The mean ± SD NLR of AD patients was significantly higher than that of patients with normal cognitive function (3.21 ± 1.35 vs. 2.07 ± 0.74, p < 0.001, respectively). Receiver operating characteristic curve analysis suggested that the optimum NLR cutoff point for AD was 2.48 with 69.29% sensitivity, 79.43% specificity, 82.30% positive predictive values and 65.30% negative predictive values. Logistic regression analysis showed that elevated NLR (OR: 4.774, 95% CI: 2.821-8.076, p < 0.001) was an independent variable for predicting AD. Elderly people with AD have higher NLR than healthy controls. Elevated NLR levels are usually considered as an inflammatory marker. The results of this study suggested that inflammation plays a role in the pathogenesis of AD.Keywords
This publication has 34 references indexed in Scilit:
- The role of inflammatory processes in Alzheimer’s diseaseInflammopharmacology, 2012
- Inflammation in neurological and psychiatric diseasesInflammopharmacology, 2012
- Alzheimer’s Disease Is Associated with a Low Prevalence of HypertensionDementia and Geriatric Cognitive Disorders, 2012
- Neutrophil-Lymphocyte Ratio as a Predictor of Adverse outcomes of Acute PancreatitisPancreatology, 2011
- Alzheimer's DiseaseThe New England Journal of Medicine, 2010
- Peripheral Cytokines and Chemokines in Alzheimer’s DiseaseDementia and Geriatric Cognitive Disorders, 2009
- Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatmentCancer Immunology, Immunotherapy, 2008
- Preoperative Neutrophil‐to‐Lymphocyte Ratio as a Prognostic Predictor after Curative Resection for Hepatocellular CarcinomaWorld Journal of Surgery, 2008
- The Baseline Ratio of Neutrophils to Lymphocytes Is Associated with Patient Prognosis in Advanced Gastric CancerOncology, 2007
- Usefulness of an Elevated Neutrophil to Lymphocyte Ratio in Predicting Long-Term Mortality After Percutaneous Coronary InterventionThe American Journal of Cardiology, 2006