The tyrosine kinase Src promotes phosphorylation of the kinase TBK1 to facilitate type I interferon production after viral infection
- 3 January 2017
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Signaling
- Vol. 10 (460)
- https://doi.org/10.1126/scisignal.aae0435
Abstract
The tyrosine kinase Src couples activation of multiple pattern recognition receptors to the production of type I interferon.Keywords
Funding Information
- National Key Basic Research Program of China (2010CB911903, 2013CB530500)
- “Shuguang Program” of the Shanghai Education Development Foundation and the Shanghai Municipal Education Commission (15SG32)
- National Natural Science Foundation of China (81471566, 81222039, 81172851, 30972674)
This publication has 50 references indexed in Scilit:
- Structural Biology of Innate ImmunityAnnual Review of Immunology, 2015
- The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and SignalingMolecular Cell, 2014
- Innate immune detection of microbial nucleic acidsTrends in Microbiology, 2013
- cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STINGNature, 2013
- Structural mechanism of cytosolic DNA sensing by cGASNature, 2013
- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon PathwayScience, 2013
- The role of pattern-recognition receptors in innate immunity: update on Toll-like receptorsNature Immunology, 2010
- Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6Nature Immunology, 2004
- Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling PathwayScience, 2003
- Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor SignalingThe Journal of Immunology, 2002