Intragraft Levels of Foxp3 mRNA Predict Progression in Renal Transplants with Borderline Change
- 1 December 2008
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of the American Society of Nephrology
- Vol. 19 (12), 2277-2281
- https://doi.org/10.1681/asn.2008030254
Abstract
The optimal therapeutic management of borderline lymphocytic infiltrates in renal allografts, described by Banff criteria, is unknown, largely because of the inability to predict clinical outcome in these cases. For determination of molecular factors that may predict outcome in cases of borderline change histology, mRNA levels of Foxp3, Granzyme B, IFN-γ, IL-23, and RORγt were measured in renal tissue from 46 untreated patients. Twenty-five patients were considered “nonprogressive,” defined by a serum creatinine that remained 110% from baseline and by repeat histologic examination within 40 d showing progression toward acute rejection. Only Foxp3 mRNA levels were significantly higher in nonprogressors than in progressors (P = 0.001). Analysis of receiver operating characteristic curves demonstrated that the outcome for patients with biopsies showing borderline change could be predicted with 90% sensitivity and 79.1% specificity using the optimal Foxp3 mRNA cutoff value. Our findings suggest that the measurement of Foxp3 mRNA offers a means of improving prediction of outcome of borderline change.Keywords
This publication has 20 references indexed in Scilit:
- HLA-Mismatched Renal Transplantation without Maintenance ImmunosuppressionNew England Journal of Medicine, 2008
- Phenotypic and functional features of human Th17 cellsThe Journal of Experimental Medicine, 2007
- Banff ’05 Meeting Report: Differential Diagnosis of Chronic Allograft Injury and Elimination of Chronic Allograft Nephropathy (’CAN’)American Journal of Transplantation, 2007
- The Regulatory/Cytotoxic Graft-Infiltrating T Cells Differentiate Renal Allograft Borderline Change From Acute RejectionTransplantation, 2007
- Transient expression of FOXP3 in human activated nonregulatory CD4+ T cellsEuropean Journal of Immunology, 2006
- Interleukin-23 drives innate and T cell–mediated intestinal inflammationThe Journal of Experimental Medicine, 2006
- Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsNature, 2006
- Early protocol renal allograft biopsies and graft outcomeKidney International, 1997
- Significance of the banff borderline biopsyAmerican Journal of Kidney Diseases, 1996
- Correlation between Banff classification, acute renal rejection scores and reversal of rejectionKidney International, 1996